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The Third Cannabis Receptor Site – GPR55

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We talk all the time about the two cannabis receptor sites in the body, CB1 and CB2. Scientists, however, have uncovered what appears to be a third cannabis receptor site, GPR55. What is this site? And how does it impact things like inflammation, cancer, and anxiety?

CB1 and CB2 might be the main cannabis receptors, but a third cannabis receptor site exists called GPR55. Perhaps in the future, this receptor site will play a bigger role in the research and development of cannabis products. For now, there are plenty up for grabs, including a growing array of cannabis cannabinoids including delta-8 THC, THCV, and even hemp-derived delta-9. No matter what your favorite delivery method, we’ve got a product for you. Check out our deals, and start your holiday shopping today!


CB1 and CB2

To start with, humans (and other animals) have an endocannabinoid system which is a neuromodulation network throughout the body. This system is highly important to central nervous system functioning, as well as being involved in synaptic plasticity, and the response to different stimuli, whether from inside or outside the body. The system involves cannabinoid receptors, endocannabinoids (or endogenous cannabinoids made in the body), and the enzymes that are required for the synthesis and degradation of endocannabinoids.

There is currently plenty of research going on involving the endocannabinoid system, and how it functions. Research findings have pointed at the endocannabinoid system being related to the regulation of cognitive as well as physiological processes, like fertility, pregnancy, and natal and early development.

It is also thought to play into immune activities; mood, emotion, and motivation; memory and learning; appetite; pain sensitivity and modulation; behaviors involving addiction; and neural functions like motor coordination and control. And of course we can’t forget its also responsible for producing the psychoactive effects of cannabinoids like delta-9 THC.

GPR55

When it comes to the receptors, there are several, however the two of main interest, and which have been studied the most, are the CB1 and CB2 receptors. CB1 was first cloned in 1990, and those receptors are found mainly in the brain and nervous system throughout the body, including in other organs and tissue.

CB2 receptors are found in the brain (though far less than CB1 receptors), and in the immune system and gastrointestinal system. CB1 receptors therefore are regulators of neural transmissions and many peripheral purposes, and CB2 receptors are more geared toward regulating immune and inflammation pathways.

In terms of THC, “THC acts as a partial agonist at cannabinoid receptors (CB1 and CB2). A very high binding affinity of THC with the CB1 receptor appears to mediate its psychoactive properties (changes in mood or consciousness), memory processing, motor control, etc. It has been reported that a number of side effects of THC, including anxiety, impaired memory and immunosuppression, can be reversed by other constituents of the cannabis plant (cannabinoids, terpenoids, and flavonoids).”

Third cannabis receptor site – GPR55

CB1 and CB2 receptors are only two types of receptors found in the endocannabinoid system, but others exist. One atypical type of receptor, often thought of as the third cannabis receptor site, is GPR55. This receptor, first found in 1999, is still being studied, and not a whole lot is known about it for sure. However, it’s expected that it’s responsible for many of the effects of different cannabinoids, leading some to refer to it as cannabinoid receptor site 3. In actuality, it has not yet been given an official CB3 designation, but that could be coming.

GPR55 (or, G protein-coupled receptor 55) is thought of as a ‘type 3’ receptor, which is activated by cannabinoids like delta-9, as well as non-cannabinoid ligands. A ligand is a grouping of like molecules that can attach to receptor sites, and in this case refers to either endocannabinoids (made within the body), phytocannabinoids (produced by the plant), synthetic cannabinoids (made in a lab), and non-cannabinoids. So this means the receptor is activated by cannabis related compounds, and non-cannabis compounds as well.

GPR55 receptor actions have been seen in the nervous system; parts of the brain like the frontal cortex, cerebellum, striatum, hypothalamus, and brain stem; and in dorsal root ganglia neurons; the spleen; tonsils; adrenals; bones; endothelial cells; large intestine; lungs; kidneys; and adipose tissue (or body fat).

CB1 CB2

In the brain, these receptors seem to be related to the perception of pain, neuroprotection, anxiety issues, motor coordination, and substance abuse issues. Apart from these attributes, GPR55 is also thought to be involved in the formation of bone, the experience of neuropathic pain, inflammation, and fetoplacental development.

What third cannabis receptor site GPR55 shows in research

So, what is this third cannabis receptor site GPR55 known for? Well, its still being researched, but there are several different attributes it’s being studied for. One of them has to do with how these receptors effect cancer. These receptors are associated with many different kinds of cancer, and can be found within cancer cells.

One of the things about GPR55, is that it seems (at least at times) to promote the proliferation of cancer cells. In general, something that helps cancer spread is not thought of as good. In one study it was found that the knocking down of the GPR55 expression in glioma cells (essentially using glioma cells where GPR55 expression has been muted) was related to decreased tumor growth. As in, when the receptors weren’t functioning, tumors didn’t function as well either. Another study showed the expression of GPR55 in different prostate and ovarian cancer cell lines.

Learning how GPR55 effects cancer cells, is useful for understanding how cancers grow, and how to treat them. For example, recently developed antibodies that work against GPR55, can detect it’s expression at protein levels in tumor tissue and normal tissue. At CB1 and CB2 receptors, cannabinoids act as agonists, and have been shown to be useful for fighting cancer because of antiproliferative, antimetastatic, antiangiogenic, and pro-apoptotic effects. Agonists of GPR55 are known for their pro-cancer effects.

THC has been shown to be an agonist sometimes with GPR55, but not always, leading to reasonable confusion as to how the receptors are effected by delta-9, and whether the effect created is positive or negative.

One of the big avenues of research for this third cannabis receptor GPR55, is regarding its anti-inflammatory properties. For example, in one study, the increased expression of GPR55 suggested a relationship with intestinal inflammation. In fact, GPR55 seems to play a pro-inflammatory role according to some research. Other research shows the opposite, like it having an anti-inflammatory expression on mast cells, by way of inhibiting mast cell-mediated releases of nerve growth factor. Investigating different agonists and antagonists of GPR55 can help us better understand how it’s used for inflammatory and anti-inflammatory purposes. Both are necessary for bodily function.

The takeaway? “The orphan G-protein-coupled receptor 55 (GPR55) has been reported to modulate inflammation and is expressed in immune cells such as monocytes and microglia.” Of course, specifics to all this are still quite unknown.

cannabis receptors

Yet another attribute has to do with its use with anxiety, which is also still not well understood. In one study on mice with the GPR55 receptors silenced in the medial orbital cortex (knockout mice), it was found that use of O-1602 (synthetic compound somewhat related to abnormal CBD), which had previously shown to work as an anxiolytic in acutely stressed mice, no longer had this effect without use of the receptor. This indicates that the receptor might play an important role in experiencing anxiety, with its suppression effecting how anxiolytic compounds will behave.

GPR55’s existence in the central and peripheral nociceptive systems (the systems whereby we sense and experience pain), implies a possible ability to modulate these pathways. It has even been proposed that GPR55 (as well as receptor GPR18) could play a part in the experience of both acute and chronic pain. Research already suggests that GPR55 is related to the modulation of nociceptor excitability, meaning it can play a role in how we respond to painful stimuli. In terms of nerve damage, GPR55 was found to show mRNA expression in both the spinal cord and DRG (dorsal root ganglion) of nerve-damaged test rats, suggesting a link between GPR55 and neuropathic pain. Studies are across the board at the moment, with much further research needed.

Conclusion

Even though we talk about CB1 and CB2 receptors a lot, it doesn’t mean they’re the only ones at all, and in fact, other receptor sites have been found. Third cannabis receptor site GPR55 might not technically be called CB3 at the moment, but it might soon, and for good reason. It seems to play a big role in how cannabis is capable of effecting the body, though the jury is still out on exactly what this means in different contexts.

What is for sure is that cannabis is a plant with many and varied compounds capable of having many and varied effects. Perhaps GPR55 represents an avenue of cannabis we are still not as familiar with, and points us in an important direction for future cannabis study.

Welcome everyone! Thanks for stopping by CBDtesters.co, the best internet location for all cannabis and psychedelics-related news, offering up the most current and interesting stories of today. Come for a visit regularly to stay informed on the quickly-moving universe of legal drugs and industrial hemp, and don’t forget to check out the The Delta 8 Weekly Newsletter, to get every important news story first.

For more articles like this one, make sure to subscribe to The THC Weekly Newsletter. Also save big on Delta 8Delta 9 THCDelta-10 THCTHCOTHCVTHCP & HHC products by checking out our “Best-of” lists!

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.





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DIY: How to Make Your Own CBN

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There’s a lot of talk about different cannabinoids, and the growing unregulated cannabinoids market. One of the cannabinoids of interest is CBN, for its possible ability to help with sleep. Unlike many cannabinoids which require synthetization, CBN can be made pretty easily, and not as a synthetic. Read on for tips on how to make your very own CBN.

With a wide-ranging cannabinoids market out there, there are now tons of ways of enjoying cannabis besides standard THC. Whether you’re interested in delta-8 THC which causes less anxiety, CBN which might be good for promoting sleep, THCV which has shown as a possible aid in weight loss, or HHC a minimized version of THC, options abound, and we’ve got plenty for you. Check out all our deals on these compounds, and find the ones that work best for you.


What is CBN

Before getting into how to make CBN, we need to know more about what it is. The cannabis plant is made up of many components including flavonoids, terpenes, chlorophyll, lipids, cannabinoids, and other compounds. In fact, the main association with cannabis, is the cannabinoid delta-9 THC, sometimes erroneously called ‘THC’. This term actually stands for ‘tetrahydrocannabinols’, which can involve more cannabinoids than just delta-9, but somehow that slang term has prevailed, even showing up in medical literature. However, what we are actually speaking of, is delta-9 THC.

Cannabis plants can be split into two general types of plants, though both categories fit under the umbrella of ‘cannabis’. One, which we refer to as ‘hemp’ has lower amounts of delta-9 (which actually shows in a live plant as the acid THCA), and higher amounts of CBD (which shows in a live plant as the acid CBDA). On the other hand, ‘marijuana’ is now the term used for plants higher in THCA than CBDA.

Both THCA and CBDA are ‘phytocannabinoids’ because they appear in the plant. And both convert in the presence of light and heat to their respective cannabinoid counterparts THC (delta-9) and CBD. But this is not the end of the story. Once converted to delta-9 and CBD, these new cannabinoids can eventually degrade further into what we call ‘degradants’. These degradants can be entirely new cannabinoids. And this is where CBN comes in. CBN is the main degradant of delta-9, for which the vast majority of delta-9 will become. This makes CBN a rather prevalent cannabinoid in comparison to others like delta-8 or THCV, which only ever show in miniscule amounts. The chemical formula for CBN is C21H26O2, and it’s considered only minorly intoxicating.

make CBN

While it’s hard to say exactly what CBN is capable of, there is a growing belief that it could be related to properties like the ability to help with sleep and anxiety. This thought came around because of the noticed effect of older cannabis (which is more degraded than a new flower), making people more relaxed and tired. Plenty of research is currently being done into the possible existence of these properties. Apart from a sleep aid, CBN has many other similar benefits to delta-9 THC and other cannabinoids.

The history of CBN

Weirdly enough, CBN was the first cannabinoid of the cannabis plant to be discovered. This was not the goal at all, though, as the goal was to find the intoxicating element of the plant, for which CBN was confused. This research to establish the intoxicating element was already underway in the late 1800’s, being led by different scientists, namely Thomas Easterfield. And it was his discovery that led to the finding of other cannabinoids like CBD and THC.

To find this intoxicating element, cannabis was distilled into what was referred to as a ‘red oil’, and this was the first form to be studied in modern times. This red oil was discovered by Dr. Thomas Easterfield, who was a member of the Cambridge Group, and a lecturer at Cambridge University. When he first wrote about this ‘red oil’, he gave it the name ‘cannabinol’. These days we know that term to specifically mean the compound CBN, but at the time, it was related to the red oil distilled from the plant, as well as what was thought to be the intoxicating factor.

It was thought at that time that cannabinol was a narcotic substance, which was later clarified to be untrue. Easterfield was the first to isolate cannabinol, which, he stated in his late 1800’s writing, as being the intoxicating factor. Perhaps Easterfield would have gotten further, but a couple incidences got in the way of research.

One involved the accidental death of two collaborators in a lab accident. The other is a strange story of the voluntary ingestion of a large dose of CBN by another guy, leading to this guy getting extremely high and somehow catching on fire. Don’t worry, it was extinguished and he was fine, but research stopped upon media reports exaggerating the circumstances for smear campaigns against cannabis (started that early!) Research was halted for decades.

Things didn’t really pick up again until the 1930’s when Dr. Robert S. Cahn began studying CBN again. Cahn started calling the red oil ‘crude cannabinol’, and started using the term ‘cannabinol’ for the actual cannabinoid compound. Through his research he was able to validate that CBN was not the intoxicating factor. Cahn did map the structure of CBN, but many questions were still left unanswered until future scientists finally discovered CBD and THC. Separately, Easterfield and Cahn made the initial discoveries into CBN.

CBN

How to make CBN

When it comes to how to make CBN, the important thing to remember is that it’s a degradant of delta-9 THC, and that means you can make CBN from regular marijuana. Though it can be made from a hemp plant, since a hemp plant has considerably less THCA, it would require synthetization, rather than being made naturally. The best way to make CBN, therefore, is by using high-THC marijuana plants.

So how do you make CBN? It’s actually quite easy. Just add the things that naturally convert THC to CBN, light and/or heat. Both of these options essentially speed up time, allowing for a quicker degradation process that allows for CBN to be made. When made industrially, CBN is often created using solvents and metallic catalysts. However, if you do it yourself, not only do you know you’re getting the right product, but you can actually make a cleaner product. This can go for many cannabis products, where DIY methods can often net a better result when done correctly.

Heating: If you want to use the heating method (and you probably do as its more defined), you need to go through the regular process of decarboxylation that turns THCA into delta-9. However, in this case, you need to go a little further, to degrade the delta-9 in order to make CBN. Regular decarboxylation to convert THCA to delta-9 is usually done for no more than 20-40 minutes at a temperature of 230-250°F. These temperatures are low enough that the further conversion to CBN and degradation of other plant compounds, isn’t a problem. In this case, though, you would decarb at higher than 302º F, for a total of 15 minutes, although some publications say that 300º F for one hour also works. And that’s it. After this, you can go on to use the bud to make oil, butter, or whatever other product you know how to make, or can find instructions for.

UV light: The other option to age the plant in order to make CBN from delta-9, is with UV light. Unfortunately, less has been published about the specifics for this method, apart from the fact that a very intense light would need to be used. How intense, and for how long, is harder to say. Perhaps in the future, as CBN becomes more popular, this topic will get further flushed out.

There is, however, plenty of information about how light effects the cannabis plant, and much can be gleaned from this explanation:

“In cannabis, Δ 9-tetrahydrocannabinol (THC) naturally degrades to cannabinol (CBN) over time. Light exposure supplies energy and speeds up this process. The ratio of THC to CBN in a stored sample of cannabis can actually be used to indicate age and quality of storage.

Lindholst (2010) examined tetrahydrocannabinolic acid (THCa) in cannabis extracts. Samples exposed to daylight degraded at a half-life of 35 days, while those kept in darkness degraded at a half-life of 91 days (an approximate 250% difference).”

Cannabis UV light

While this is not specific, it does indicate that if you leave your weed out in bright sunlight, or put it under a UV light, that the process of converting delta-9 to CBN is much faster. I didn’t see an exact consensus on how to do this online, but several message boards contained different instructions by different people, and interested parties should check through to find more specific information if this is a desirable method to try. Personally, I suggest using the heat method.

How this differs from other minor cannabinoids

The cannabinoids market of today offers tons of options of both naturally occurring and synthetic cannabinoids. What’s the catch? Even the naturally occurring ones (besides THC and CBD) don’t occur in high enough amounts for extraction without synthetization. Meaning if you’re buying a product, even if it’s something like delta-8, which most definitely is naturally occurring (as likely another minor degradant of delta-9), your product will have gone through processing. This likely means the involvement of harsh chemicals or processes that may not be safe, and which aren’t currently being regulated.

Beyond that, the lack of regulation means its hard to know you’re getting the product you’re paying for, and that it’s not a fake, or filled with adulterants. For this reason, this has become a questionable market in terms of safety and product quality. And this goes for any cannabinoid product that fits the category of requiring synthetization. It also goes for many other cannabis products, but minor cannabinoids in particular we already know cannot be easily and directly extracted for use.

The difference with CBN is that it can be made to appear in large enough amounts, by simple methods that don’t involve synthetic processing. However, for the other reasons mentioned, this doesn’t mean that because you’re buying a CBN product, that it will be real. And that brings us to the other difference with CBN and other minor cannabinoids. Much like delta-9 itself, it can be made DIY style, giving users the ability to make a clean product, and to know for sure what that product is.

Conclusion

CBN likely has plenty of medical benefits, and one seems to be the ability to help with sleep and anxiety, though this is not formally stated. Research has been inconclusive, and is ongoing, but message boards are already filled with people talking up these qualities. Perhaps in the future we’ll know more. Let’s remember one thing. The government never likes when people can make their own products, or buy them outside of regulation, since it means less money in taxes for the government.

The push to say CBN isn’t effective for sleep could be more related to trying to save it for the pharmaceutical market, or simply to keep people from buying it, than trying to help people find a safe method to promote sleep. This is supposition, but something to consider in the whole ongoing cannabis debate, and with the rapid growth of the government backed pharma market.

Hello and Welcome! Thanks for making it to CBDtesters.co, the internet’s preeminent location for the most important and though-provoking cannabis and psychedelics-related news globally. Visit us whenever you can to stay on top of the always-in-flux universe of legal drugs and industrial hemp, and remember to check out The THC Weekly Newsletter, to ensure you always know what’s going on.

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advice, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.





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Marijuana Company Curaleaf Pays Out For Tainted CBD Products

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CBD is a dicey subject because of laws relating to the legality and sale of products. This extends to most retailers as no regulation exists federally, and is not always followed by states. As an example of the growing issues in the industry, well-known company Curaleaf, just had to pay out as a result of lawsuits about tainted CBD products.

Curaleaf and its tainted CBD products highlight a major regulation issue in the legal cannabis industry, but this doesn’t mean there aren’t good products, just that consumers must do their due diligence. This is also true of the cannabinoids market which contains products like delta-8 THC, THCV, and HHC. Remember to subscribe to The THC Weekly Newsletter all the latest news and industry stories, as well as exclusive deals on flowers, vapes, edibles, and other products. Also save big on Delta 8Delta 9 THCDelta-10 THCTHCOTHCVTHCP & HHC products by checking out our “Best-of” lists!


What’s the news?

The Massachusetts-based company Curaleaf, which also operates out of facilities in Oregon and as well as being on the Canadian stock exchange as CURA, found itself in hot water this year with 10 lawsuits waged against it for selling tainted CBD products. How were they tainted? They contained a large dose of THC, which was not listed on the packaging, and not a part of the marketing for the products.

The products in question are Curaleaf’s Select brand CBD Wellness Drops, which the company says workers in a Portland facility managed to confuse with THC drops. The CBD drops are made from hemp, and are not supposed to have THC in them, or at the very least, not in the large quantity that apparently made it in.

Curaleaf paid out $50,000 to settle a case in September, brought on by Ayuba Agbonkhese, an Idaho resident who claimed he ended up in an emergency room after ingesting the drops without knowing their THC content. Agbonkhese specifically wanted the public to know all the terms of this deal, in order to bring more awareness to this tainted products problem. He is, in fact, quite correct about the size of the problem, and the need for more attention on it. In his words:

CBD settlement

“It was important for me to make sure that the company, as well as other companies like this, become more accountable. I want a safer community. That is my main reason for doing this in this way… I want them to be better and I want the industry to be better.” Apparently, though Curaleaf did pay out, it did not see fit to formally apologize.

Agbonkhese is not the only person to have an issue. At least four others had to be treated in an emergency room after using the same tainted CBD products. Agbonkhese’s case was the only one where the terms were made public, but nine other cases total have been settled by Curaleaf for its tainted CBD products.

Is that it?

Nope. Three other cases remain open, including a wrongful death suit. Honestly, while Curaleaf represents a huge issue in the CBD industry, the wrongful death case does seem to be a stretch, and also likely representative of opportunism for a payout. In that particular case, the person died weeks after ingesting the drops, and was otherwise sick, making the claim not only a bit silly, but unwise considering it dilutes what are actual and legitimate claims.

The Oregon Liquor and Cannabis Commission (OLCC) is currently investigating Curaleaf. Curaleaf acquired Cura Cannabis (Select), in 2019, and has sold hundreds of tainted CBD products throughout Oregon in the past year. It should be mentioned, that while an unexpected THC overdose is certainly not fun, and in these cases, 100% unexpected, it is also non-lethal. But the whole idea of tainted CBD products begs the question of whether there could be other issues with Curaleaf’s products, and similar products on the market.

Curaleaf did recall both the products in question, the Select CBD Wellness Drops, and the high-THC drops. But this happened because they were forced to by Oregon regulators. The OLCC has been investigating the situation since that time, as it represents the first time this has really become a large news story.

While Curaleaf has said very little about the settlements, it has stated that the cause of these issues was ‘human error’, and that processes have been updated as a result of the incidences. The company has not stated whether anyone was held accountable, or how these mistakes were actually made. As it was an ongoing issue with this company that spanned months of time, these questions are very relevant, along with what else could be wrong with these products if they haven’t gone through the testing they were supposed to.

tainted CBD products

The problem with the CBD industry

The main issue with the CBD industry at large, is that it’s not federally legal, and therefore not federally regulated. The reason CBD is technically illegal for food, as a supplement, or a non-prescription medicine, is that CBD is already the active ingredient of an approved pharmaceutical medication (Epidiolex), and under US law, once a compound is an active ingredient in an approved medication, it can no longer be marketed as a dietary supplement, or be used in food products. Therefore the CBD industry in the US at large (with a few exceptions), isn’t legal, and products on the market are not being regulated for what is in them.

However, this doesn’t actually apply to Oregon as a legalized state. Since Oregon set laws counter to the US federal government, though it is breaking federal law with these sales, it’s legal due to state laws. And that means CBD sales are perfectly legal in Oregon, and able to be regulated!

There is a lot that’s said about the growing cannabinoids industry in the US, which includes CBD as well as minor cannabinoids like delta-8 THC, THCV, and HHC. There is increasing wariness of the industry, and for good reason, as it operates 100% as an unregulated black market, selling products outside of legal dispensaries, offering illegal merchandise online, and creating black market testing facilities to give the illusion of regulation, though these have repeatedly shown to be scams.

But once again, Oregon is a legalized state, so these issues, though still existent since synthetics are not legalized in the state, at least shouldn’t apply to the CBD industry. And yet, we can see they clearly do. If Curaleaf had this ongoing issue for months, then whatever product testing it was supposed to be doing that whole time, obviously wasn’t being done at all. If this is the best we can expect out of a legal company, it really doesn’t imply anything good about any delta-8 company, or any other company not working within legal parameters.

What this means is that there are substantial problems with getting things done properly in the cannabis industry. Whether this is because companies don’t have the money to pay out to testing facilities, whether bribes are being made to pass products illegally, or if this simply represents greed by large companies (we see this literally all the time), is hard to say. But when the legit industry starts looking like the black market, you know there’s definitely a problem.

What this means for buyers

While this problem could be specific to Curaleaf, nothing about this industry indicates it is, and if a bigger company with means isn’t going about things properly, what can we realistically expect of the rest? On the other hand, big corporations are sometimes known for being a lot dirtier in their practices than smaller mom and pops. Perhaps it indicates more a showing of the general corporate attitude of not caring about consumers, let alone their own workers, than an actual inability to create decent products consistently.

know your brands

This undoubtedly creates a big issue for users, when what are seen as legit companies cannot be trusted. Ordinarily I say ‘know your brands’ and perhaps this is still the best answer, but it’s not a great one. With newer industries, after all, the idea of knowing a brand is limited to only the recent future, and sometimes, like with CBD products, without any history of other products to know them by. As such, the idea of knowing your brands is not as easy as it might be when buying other products with more established brands.

It does mean that customers are now really put to the task of doing due diligence. Especially if they don’t want to solely depend on state regulators to decide if a company is safe, and if its doing everything it’s supposed to be doing to ensure safe products, that are what they say they are.

Conclusion

Truth is, I expect there to be more of these cases. The weed industry is a dirty place these days, way dirtier than when it was a 100% illegal industry. So far, legalizations have done nothing but get us overpriced dispensaries, massive fakes markets, and adulterated products. If not for the fact that it might be slightly harder to get arrested in some places, not much really good has been accomplished by all this, with Curaleaf standing as a beacon to this sentiment.

Welcome to CBDtesters.co, your #1 internet spot for all the most important and thought-provoking cannabis and psychedelics-related news relevant today. Visit us whenever you can to stay educated on the fast-paced universe of legal drugs and industrial hemp, and remember to check out The THC Weekly Newsletter, so you never miss a single thing.

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advice, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.





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How to Get Supplements to Work? Change Your Life

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There are some very intense realities to life, and one is that if you really want change, you need to really make changes. Though the addition of supplements may be useful, if you really want them to work, you might need to change other aspects of your life.

Supplements can improve your health, but if you really want them to work, you might need to change other parts of your life. The cannabis plant provides many compounds that can be used as supplements for sleep, weight loss, stress reduction, and more. Remember to subscribe to The THC Weekly Newsletter for deals on legal cannabis products, as well as all the latest news and industry stories. Also save big on Delta 8Delta 9 THCDelta-10 THCTHCOTHCVTHCP & HHC products by checking out our “Best-of” lists!


Supplements

These days there are supplements for pretty much anything. You don’t eat meat and you’re not getting enough B12? Well, there’s a capsule for that. Not enough fermented foods in your diet and your guts are acting up? Take yourself a probiotic. Eating a diet full of omega-6 and you feel a little swollen, best to swallow down some fish oil. Overweight and trying to deal with it, maybe add some THCV into your diet.

A supplement is something that is added into a diet, generally to make the addition of something that is lacking, or for a particular purpose. Supplements generally contain “minerals, herbs or other botanicals, amino acids, enzymes” as well as other possible ingredients. They can come as tablets, gummies, capsules, tinctures, oils, powders, drinks, energy bars, and pretty much any other way to get something in you.

A lot of things can be used as supplements in a diet, although the term ‘dietary supplement’ is a specific term made by congress that rules out many compounds. Some supplements are taken specifically to obtain nutrients that aren’t being acquired in a regular diet. These kinds of supplements can be for essential nutrients which are not made by the human body, (and must be taken from the environment around), or non-essential nutrients which the body can produce, even if it can’t produce enough. Examples of essential nutrients are fats like omega-3, amino acids like lysine, vitamins like vitamin A and the vegan-loved B12, and minerals like calcium, magnesium, and zinc.

Nonessential nutrients are those that can be made in large enough quantities by the human body, but for whatever reason are lacking. Nonessential nutrients include amino acids like tyrosine and L-cysteine, and vitamins like vitamin D and biotin. Another thing not produced by the body (though not considered a nutrient) is fiber, which many people also take as a supplement to improve digestive function.

‘Dietary supplement’ is a legal definition for what can be sold in a specific category, so not everything that acts as a supplement, is considered a dietary supplement. Insulin is a good example of this. It is most certainly supplemental, but not considered a supplement by definition. This is also legal, as insulin is in approved medications, and therefore can’t be marketed as a supplement.

Not all supplements were created equally, and this must be remembered. The supplements market is not regulated, and therefore, though the market is legal, what can go into products is not defined. This makes it a ‘know your labels’ industry, as cheaper brands might put in additives, use lesser quality materials, or sell you the wrong thing altogether. There is also the issue of chemicals used.

A supplement will contain several other ingredients not related to the actual purpose of the supplement. Think about the capsule it might be in, something put in it to keep it from spoiling, or whatever makes it that bright blue color. Depending on what you want to stay away from in life, picking the right supplements as per the desired ingredients, is also important.

Do supplements work?

This is a great question in life, and different people will give you different answers. The most honest answer is, sometimes it’s hard to tell. If a person isn’t taking something where they expect to see a direct effect, it might be hard to tell if there is one. There are a lot of factors that can complicate life, and its often hard to tell exactly what is causing each response.

Many supplements fit the bill for ambiguous results. If a vegan is taking B12 to make up for not ingesting animal products, and their energy improves, it will still be hard for them to rule out other factors that could’ve caused the improvement. Maybe they simultaneously also started getting more sleep, or inadvertently upped protein without realizing it, through a dietary change.

When a person takes an antibiotic to kill an infection, an improvement in symptoms will generally be related to that medication. If a person has an infected cut that won’t heal on its own, and then the application of hydrogen peroxide or alcohol decreases infection, the two are likely correlated. Does it mean they have to be related? No, but in general practice, they are.

If a supplement is taken for something that it can help with, it probably will. Think about people with diabetes. Technically, the insulin they take is supplemental because its not the insulin made by their bodies. We consider insulin a medication, not a supplement, because its in approved mediations, but this doesn’t change that its acting as a supplement.

Generally, taking insulin will reverse symptoms by temporarily solving the problem of not enough insulin produced in the body. For a Type I diabetic, insulin is actually an essential supplement, because the body isn’t producing enough. Whereas for Type II, its nonessential because there isn’t a problem with production, but rather with production being enough for an expanded body size (assuming the issue is weight). In the case of diabetes, the user will most certainly know if the supplemental insulin is working.

The above example is very different from a person supplementing with something like probiotics. In this case, the difference can still be incredibly intense, but it won’t necessarily be quite as direct, and can often take a long time for full effects. Probiotics can be very useful, and I personally attest to the difference it can make in the digestive tract when a person consistently takes a quality product.

Best way to make supplements work, is to change your life

This is not a desired headline for many people, but it’s still mostly true. Unless a supplement is always going to work for everyone, there isn’t a guarantee for effectiveness. Realistically, this is also relevant for the standard medical world. Think of how often we speak of antibiotic resistance… well, that denotes people not getting the intended effect of the antibiotic. Supplements might work better in some bodies than in others, but there is still a hard and fast truth to easy answers.

Let’s be honest, most people take supplements to solve a problem, or improve their health in some way. Like taking those probiotics. It’s a great idea, BUT, if a person is going to continue with bad habits, the probiotics might not be very effective. If a person is eating a diet full of chemicals and processed foods, simply taking a probiotic might not be enough to counter or reverse years of internal damage and the continuation of what caused the damage in the first place. If you are concerned enough about your digestive health to take a probiotic regularly, you might want to consider a change to your life in the form of a better actual diet.

Another example is if a person is having problems sleeping, and attempting to remedy the situation by taking a CBN product. Expecting the CBN to work, despite ingesting caffeine and living by a schedule not conducive to good sleep, is a little off base. But if the person in question also takes caffeine out of their diet, gets some exercise, and works their schedule to be more conducive to a natural sleep cycle, that supplement might work way better.

To some, this takes away the idea of the easy answer, but realistically, easy answers don’t exist. The person with sleeping problems might require something more to help sleep, even despite making lifestyle changes. However, this doesn’t mean a certain amount can’t be achieved through those lifestyle changes alone. It also doesn’t mean the supplement absolutely will work if changes are made, but better overall lifestyle habits can influence overall supplement performance.

One of the biggest issues where supplements come into play, is weight loss. Everyone wants an easy answer, and no one wants to do the work. Whether the work means getting to the gym and working out, or establishing a healthy diet that promotes weight loss, (or more likely, both together) it’s incredibly common for people to try to cut corners with bad diets, and supplemental weight loss products. Compounds like ephedra, or the cannabis cannabinoid THCV, are examples of supplements used for dieting. However, if you pay attention to what goes on in the world of weight loss, you already know that if you want to lose weight, its not about the pill, it’s about making a change in your life.

If a person really wants to lose weight, they’ll probably need to start exercising. If a person really wants to improve their sleep, they’ll probably have to cut out caffeine and assess other aspects of their diet and schedule. And if a person with digestive issues really wants to improve them, taking a probiotic is great, but cutting out foods that are bad for the guts, will make those probiotics way more effective.

Conclusion

Very few people will take a supplement without the notion that it’ll do something for them. However, in looking for answers, it’s not uncommon to rely on something like a supplement without considering the realities of every other aspect of life. When looking to improve health, it’ll infrequently be done by simply popping a capsule, though that capsule can still be beneficial. If you want real change, the right supplement can certainly help, but the unfortunate reality is that you’ll probably need to change your life in other ways, if you really want to chase that positive result.

Welcome… Thanks for joining us at CBDtesters.co, the internet’s one-stop-shop for all the best and most pertinent cannabis and psychedelics-related news going on currently. Stop by daily to stay abreast of the quickly-moving landscape of legal drugs and industrial hemp, and sign up for The THC Weekly Newsletter, so you always hear every news story first.

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advise, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.





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