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cannabinoid research

Does Weed Make You Nicer? Cannabis Use and Prosocial Behavior

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We all know that cannabis can certainly mellow you out and make you feel happy, connected, and balanced – but does that equate to being a characteristically “nicer” person? Researchers from the University of New Mexico believe that it does.  

In a recent study titled “Cannabis Consumption and Prosociality” published on May 19th in the journal, Scientific Reports, UNM researchers found that healthy young adults with regular and recent exposure to cannabis demonstrated higher levels of prosocial behaviors, as well as a heightened sense of empathy, compared to non-users. Additionally, cannabis users scored higher on standardized measurements of moral decision-making based on the notions of being fair and not harming others. 

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Teaching empathy  

Empathy is a key element of social interaction, and can be defined as the ability to understand and share the feelings of another person. Empathy is a building block of successful communication that enables us to better comprehend and process the emotions behind what others are telling us, and thus, allows us to form the correct responses.  

According to a meta-analysis of US citizen empathy test scores conducted over the last 30 years, our collective levels of empathy are dwindling. Based on questions pulled from the Interpersonal Reactivity Index, researchers found the levels of “empathetic concern” have been dropping sharply. They’ve been tracking this phenomenon since 1979, but noted that the most pronounced declines occurred after the year 2000. Typically, women are more empathetic than men, but that’s not always the case.  

For decades, it was believed the empathy was an inborn trait – you either had it or you didn’t. But more recent research has shown us the empathy can be taught and improved using certain therapies and training methods. The ability to have empathy hinges on various, complex psychological and physiological processes. Because of the way cannabis interacts with our bodies’ endocannabinoid system, and cannabinoid receptors are highly concentrated in regions of the brain that regulate emotion, such as the amygdala, it’s believed that cannabis can help overcome these emotional hindrances.  

“Cannabis can have an impact on a person’s ability to understand and share the feelings of others,“ explained Dr. Jan Roberts, psychotherapist and CEO of The Cannabinoid Institute, a medical cannabis education company. “But it depends on intention, type of cultivar used, and dosage,” she continued. Too little and you won’t get what you’re looking for. Too much, “and you can suppress or dull your emotions.” 

About the study  

Now, back to the aforementioned study. The research was broken down into two basic parts: testing for THC in 146 healthy university students aged 18 to 25, and providing the participants with a series of seven questions. Nearly half of the students tested positive for THC, and were aptly placed into a group together called “users”, and the rest of the students were the “non-users”.  

Researchers discovered that the “users” group scored higher in categories of “prosocial behaviors, moral fairness, moral harmlessness, and empathy quotient,”, but lower on “ingroup loyalty”. An interesting curveball here, is that female users scored higher in areas of “aggression” than non-users, whereas male users were found to be more “agreeable” than non-users.  

cannabis empathy

“Most investigations on the effects of using cannabis have focused on either negative consequences of cannabis addiction or on the physical health effects of cannabis use,” said lead investigator and Assistant Professor Jacob Miguel Vigil, UNM Department of Psychology. “Almost no formal scientific attention has been devoted to understanding other psychological and behavioral effects of consuming the plant, despite it being so widely used throughout human history.” 

Regarding other dimensions of personality, such as anger, hostility, trust of others, facial threat interpretation, extraversion, conscientiousness, emotional stability, and openness, as well as moral decision making centered on the principles of social correctness and respect for authority – no changes were noted. Researchers also found that the effects were not permanent, meaning they are almost certainly caused by the cannabis rather than being inherent personality traits in the study participants.  

“The transience of the effects supports that cannabis is triggering behavioral and perceptual changes rather than that cannabis users and non-user differ fundamentally in their baseline approaches to social interactions,” said co-author and Associate Professor Sarah Stith, UNM Department of Economics. 

“I often refer to the Cannabis plant as a super medication, relative to most other conventional pharmaceutical products, because it is not only effective for treating the symptoms of a wide range of health conditions, quickly and relatively safely, but now we have concrete evidence that it may also help improve the average person’s psychosocial health,” said Jacob Vigil, lead investigator and Assistant Professor at UNM Department of Psychology.  

“Prosociality is essential to society’s overall cohesiveness and vitality, and therefore, cannabis’ effects on our interpersonal interactions may eventually prove to be even more important to societal wellbeing than its medicinal effects,” he added.  

Research on animal models 

A second paper published the same month in the journal Neuroscience & Behavioral Reviews, titled Effects of endocannabinoid system modulation on social behaviour: A systematic review of animal studies, applied this same theory to animal subjects. In this review, researchers from University of Toronto analyzed 80 existing studies that were conducted on a variety of mammals including capuchin monkeys, rats, mice, hamsters, and gerbils.  

cannabis empathy

Above all, it was important to determine whether cannabinoids influence social behaviors and interactions in animals, like they do in humans. As it turns out, they do. In a nutshell, what the study authors discovered was that direct cannabinoid receptor agonism – achieved through “experimental administration of a range of potent synthetic cannabinoids” – decreased social behaviors in animals, while indirect [receptor] activation via “enzyme inhibition or gene-knockout” increased social behaviors. 

Simply put, cannabinoids that had firsthand interactions with the endocannabinoid system, like Delta 9 THC and other psychoactive compounds in the plant, were said to decrease social behaviors, whereas compounds that had secondhand (indirect) effects on the cannabinoid receptors, like CBD, were believed to increase social behaviors. It’s worth pointing out that, although we do share many genetic similarities with the animals from the study, there are major differences as well, especially when it comes to learned social behaviors. That could explain why direct endocannabinoid activation in humans seems more helpful in social situations, as opposed to the way it affects animals.

As the authors also note, “some research has suggested cannabis might provide some symptomatic relief for conditions involving impaired social behavior.” A growing body of evidence, both clinical and anecdotal, highlight the ability of cannabis therapies to treat anxiety and other mood disorders, which can have a profound impact on social interactions.  

Final thoughts 

Although proven effective in some cases, the general consensus is that the connection between weed and empathy, or overall “niceness”, stems from a very personalized approach to cannabis use. “Everyone is different and for people who have had more stressors or trauma in their life, they may need more CBD or CBN to affect their level of empathy,” says Dr. Jan Roberts, psychotherapist and CEO of The Cannabinoid Institute.  

“Using cannabis can get you to go beyond your ego and defense mechanisms and communicate connection, reciprocity and growth but it must be based on an individual’s mind, body and, frankly, spirit,” she added. . 

Welcome to the site! Thanks for making it to CBDtesters.co / Cannadelics.com, the top internet spot offering up fully-rounded independent news covering the growing cannabis and psychedelics industries. Stop by frequently to stay up-to-date on these dynamic industries, and make sure to sign up to The THC Weekly Newsletter, to ensure you’re never late on getting the news. 





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What is THCh? Learn Everything About Tetrahydrocannabihexol

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In the modern-day recreational cannabis market, there is a constant, ongoing race to isolate and utilize the most potent, safe, and legal compounds from the cannabis plant. Since Delta 9 THC is the unlucky one to fall into the category of federally prohibited, we look to alternative THCs to get the job done. At this point, most people have heard of Delta 8 THC, or maybe even Delta 10 and THCV, but the newest one to make waves in the industry is THCh, or tetrahydrocannabihexol.  

Discovering new cananbinoids is always exciting, with THCh we’re at 150 so far, and still counting! To say up-to-date with more articles like this one, make sure to subscribe to The THC Weekly Newsletter – your top source for industry information as well as exclusive deals on flowers, vapes, edibles, and other legal products. And save big on Delta 8Delta 9 THCDelta-10THCOTHCVTHCP & HHC products by checking out our “Best-of” lists!


What is THCh and how was it discovered? 

Delta 9 Tetrahydrocannabihexol (THCh, Δ9-THCh or n-Hexyl-Δ9-THC), along with is cannabidihexol (CBDh), are phytocannabinoids that were discovered in 2020 by the same group of Italian researchers who first isolated THCP and CBDP (tetrahydrocannabiphorol and cannabidiphorol).  

In short, THCh is a hexyl homolog of delta 9 THC. A homolog is simply a molecule that has a nearly identical structure and function to another molecule, and primary cannabinoids have many homologs. Many of the alternate THCs, like Delta 8 and Delta 10, share terpenophenolic profiles with Delta 9 but the double bond on their linear alkyl side chain varies in location (ie Delta 8 has the link on the 8th chain, whereas Delta 9 has it on the 9th chain).  

However, in the case of THCh, this compound bears a n-hexyl side chain. These are the first hexyl derivatives of cannabinoids that have been discovered thus far. The definition of a hexyl group is “an irregular, saturated radical compound of hydrogen and carbon, derived from hexane.” Often this is the result of the loss of one or more hydrogen atoms.  

THCh can be both naturally-derived and synthetically produced. When it comes to consumer products, expect the latter, as it exists in much too low of concentrations to be successfully extracted from plant matter on a regular basis. Most likely, hemp-based CBD will be converted into THC, and that would then be turned into THCh, although I’m personally unfamiliar with the exact process of how to do that. 

 

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Effects and Benefits 

Any specifics on what exactly THCh can do for us are still up for debate, but experts do have some theories on what conditions it could best treat. Initial reports indicate that THCh is effective in elevating the mood and relieving pain.  

The team that discovered this cannabinoid tested these hypotheses on mice and found that THCh was able to block the neural pathways that are responsible for the physiological detection of pain. So basically, it subconsciously stops our brains from recognizing pain. More studies are needed to back up these results, as well to further explore its potential for providing mental health relief.  

When it comes to THCs in general, the way the work is via their ability to bind with one of the two cannabinoid receptors found in the human body. CB1 receptors are found in our brains and nervous systems and CB2 receptors are found throughout the immune system and surround structures. CB1 receptors are the primary binding points for THC, which make the psychoactive effects make that much more sense.  

As far as effects go, there isn’t much to go on there either. I haven’t tried it and have not been able to find any accounts from anyone who has. That being said, it’s believed that THCh is more potent than Delta 9 THC but slightly less potent than THCP, if that helps put it into any kind of perspective.

More about CBDh 

During this experiment, researchers also discovered CBDh; it was actually the focal point of their entire study, and THCh was the added bonus. What’s unique about CBDh, compared to other compounds in the same family like CBD and CBDP, is that it binds directly to the CB receptors.  

Most CBD-type cannabinoids have very little affinity to CB receptors. They typically bind to TRPV1 receptors, which are known to encourage higher levels of anandamide production. Anandamide is a fatty acid neurotransmitter and the first endocannabinoid to be discovered. Anandamide does bind directly to CB receptors. So, simply put, CBD does stimulate those same receptors, but in a secondary, roundabout way.  

But, since CBDh is different and does engage these receptors, its pharmacological benefits could be much greater than CBD’s. In the initial study, it was determined that much less CBDh is need for pain relief and management than CBD or CBDP.  

1.2 mg/kg of CBDH reduced pain response and 2 mg/kg of CBDH significantly blocked the physiological detection of pain. Conversely, higher doses (3 and 5 mg/kg) had no pain-relieving effects. This isn’t entirely uncommon – with some compounds, going over a certain dose does absolutely nothing as the body will only process and utilize so much at a time. 

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Delta 8 THCh?  

Another isomer being discussed is Δ8-THCh, or Delta 8 THCh. It’s currently a synthetic cannabinoid categorized under the code number JWH-124 in Clemson University’s, John W. Huffman’s, research group list of cannabinoids. In total, this group has identified about 450 cannabis plant compounds, about a third of which are cannabinoids.  

Theoretically, this could be a naturally occurring compound as Delta 8 is found in very small concentrations in cannabis and is also sometimes a degraded form of Delta 9 THC; but Delta 8 THCh has not yet been isolated in the plant.  

To expand more on that degradation: Delta 9 THC, although very abundant in marijuana strains, is an extremely unstable compound. When exposed to heat and light, THC molecules start breaking down at a rapid rate. During this process, roughly 90 percent of THC becomes CBN (cannabinol, non-psychoactive), but the other 10 percent will turn into other compounds, often Delta 8 THC.  

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Any products available? 

So far, I have not been able to find any products that scream safety or legitimacy. Doing a quick google search I found a couple companies selling vape carts that supposedly contain THCh combined with Delta 8 THC. The jury is still out regarding how these two compounds work together, or if it’s even THCh in those carts. 

*** UPDATE: THCh products are arriving soon. Subscribe to The THC Weekly Newsletter and be the first to know once those products are available.

Currently, you can experience THCh in regular, full spectrum cannabis products, since it’s naturally occuring in small amounts, but you won’t find many items containing an isolated version of this cannabinoid just yet. But make sure to check back with us because as soon as decent products are available, we will do what we can to get them to our readers.

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Hello readers! Thanks for joining us at CBDtesters.co, the #1 internet location for the most recent and interesting cannabis and psychedelics-related news from around the globe. Visit the site everyday to stay abreast of the quickly-moving landscape of legal drugs and industrial hemp, and sign up for The Psychedelics Weekly Newsletterto ensure you always know what’s going on.

Disclaimer: Hi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advice, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.

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All About CBL (Cannabicyclol) – A Minor Cannabinoid No One Knows About

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Cannabicyclol, or CBL, is a non-psychoactive, minor cannabinoid found in cannabis. Research on this compound is limited and very little is known about the extent of its therapeutic potential. Based on what we know about other cannabis compounds, it’s safe to assume that CBL can be used in the treatment of many different medical conditions, but which ones would benefit most from it remain to be addressed.

What Exactly Is CBL?

As of late, researchers have identified and isolated 113 cannabinoids, including CBL, from the cannabis plant, and they estimate there are dozens more waiting to be discovered. The fact that we have solid scientific research on only a handful of these compounds speaks volumes to how limiting and asinine prohibition has been. Imagine how much we would know if cannabis wasn’t shunned in the medical community and banned for all these years.

CBL is just one of those compounds. We know it exists, we know it comes from cannabis, and we know its molecular structure is different from other cannabinoids. Beyond that, we don’t have very much to go on. CBL is a minor cannabinoid with no double bond in its chemical structure, so it doesn’t have any intoxicating effects.

Because CBL structurally comparable to other non-psychoactive cannabinoids, researchers believe it may function similarly in the human body. It is very likely that CBL interacts with our Endocannabinoid Systems the same way as CBD, CBN, CBG, and other cannabinoids lacking that double bond their carbon chains.

Also, as a minor cannabinoid, CBL could have just as much pharmaceutical potential when working synergistically with other cannabinoids, terpenes, and flavonoids. This phenomenon is known as the Entourage Effect and explains the reason many people prefer the effects of natural cannabis flower and whole-spectrum extracts as opposed to isolates and distillates. Cannabis is such a controversial substance that we often forget it is simply a plant, and it functions like many other plants that we consume regularly. In botanical therapies, the compounds are more effective working together than individually.

Are you a cannabis aficionado who would like to learn more about cannabicyclol, as will as other minor cannabinoids and all aspects of this incredible plant? If so, make sure to subscribe to The CBD Flowers Weekly Newsletter for the best of the best that this industry has to offer, as well as access to exclusive deals on flowers and other products. Or you can check out the Delta 8 Weekly Newsletter for the best deals on Delta 8 THC.

What Are The Benefits of CBL?

In general, cannabinoids can be beneficial for an incredibly diverse range of medical conditions including mental disorders, autoimmune disease, inflammation, epilepsy, pain, and digestive issues, just to name a few. When looking specifically at the benefits of CBL, we don’t have enough research to make any conclusive statements and it’ll likely be a few more years before we have any studies to reference.

Aside from the specific molecular structure of CBL, we also know that it is a very stable cannabinoid. In 2008, a study was published in which researchers examined 2700-year-old cannabis samples found in the tomb of an ancient Chinese shaman. The arid climate, grave depth, and soil alkalinity did wonders for preserve the contents of the tomb, include the cannabis flower.

Although it was lacking aroma or flavor, the samples were still green in color. As expected, THC, CBD, and other major cannabinoids had degraded, however, the ancient cannabis samples were high in CBL and CBD; both of which are products of cannabinoid breakdown.

This has a few different implications. First, it’s relevant when discussing proper storage of cannabis. If you have flower that has either been around too long or been stored improperly, you can expect it to have higher levels of CBN and CBL. Because these cannabinoids are often found together, they likely work in tandem. Also, the fact these cannabinoids are the end of the line makes them very stable, and stability is paramount when it comes to manufacturing pharmaceuticals.

The Endocannabinoid System (ECS)?

The only reason cannabinoids even work and have an effect on so many different living organisms is because of the Endocannabinoid System (ECS), a system that was only recently discovered in 1992. Simply put, the ECS is a network of neurotransmitters and receptors that exists in the bodies of all animals. Cannabinoid 1 and Cannabinoid 2 receptors (CB1 and CB2) are found in the brain and nervous system, as well as in peripheral organs and tissues.

As a whole, the ECS regulates numerous different functions and processes in our bodies and maintains internal balance and homeostasis. The ECS modulates the nervous and immune systems and other organ systems to relieve pain and inflammation, regulate metabolism and neurologic function, promote healthy digestive processes, and support reproductive function and embryologic development.

Researchers have discovered two different endocannabinoids so far, 2-arachidonoylglycerol (2-AG) and anandamide (AEA). 2-AG is made from omega-6 fatty acids and is present in fairly high levels in the central nervous system, but it has also been detected in human (and bovine) milk. 2-AG is a full agonist of both the CB1 and CB2 receptors, but it has a stronger influence over the CB2 receptor. Because of this, 2-AG is thought to have a substantial impact on the immune system. Anandamide (AEA), also commonly referred to as the “bliss molecule”, is known to play a major role in the in all our basic daily physiological functions including sleep/wake cycles, appetite, mood, and even fertility.

In addition to the naturally produced cannabinoids, there is also a large web of receptors that allow AEA and 2-AG to function the way they do. Again, the two receptors that have been studied most extensively are CB1 and CB2. These cannabinoid receptors sit on the surface of cells and monitor conditions on the outside. Once they sense changing conditions and the body falling out of a state of homeostasis, they signal the appropriate cellular response to restore balance.

What Does The Future Hold?

Considering this is one of the least discussed cannabinoids, it’s understandable that demand is low and not many companies are prioritizing CBL products. At the moment, it’s only available as a scientific research material through a handful of companies, like Cayman Chemical and Cerilliant. Eventually, that will change and just like CBN, CBC, CBG and another minor cannabinoids, more and more products will make their way to the retail sector and into the hands of consumers.

With legalization sweeping the world, a growing fascination for the medical benefits of cannabis, and vastly improved extraction and production techniques, even the most minor compounds like CBL will find a suitable market. There is such a need for non-psychoactive medicinal cannabinoids that it will be impossible and immoral to ignore the treasure trove that is found in this plant.

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Cancer

New Research Labels THCA as Novel Therapy for Drug Resistant Cancer

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THCA, or tetrahydrocannabinolic acid, is a relatively unknown compound found in the cannabis plant. Research on this cannabinoid is quite promising, despite the fact that it’s still mostly uncharted territory. However, one of the most hopeful studies to date is a new one from Israel that suggests THCA could be beneficial in the treatment of drug resistant tumors.

Medical cannabis has come a long way. From SciCann and its new-age THCA cancer treatments, to delta-8 THC – an alternative to delta-9, which won’t cause anxiety, and leaves users with a clear-headed high, and slightly less psychoactive effect. New cannabis technology means new and improved products for consumers, and that’s good for you. If you want to try what today’s world of cannabis technology has to offer, subscribe to The CBD Flowers Weekly Newsletter for more articles, exclusive deals, and to take advantage of today’s best advancements in cannabis products.  Or you can check out the Delta 8 Weekly Newsletter for the best deals on Delta 8 THC.


What is THCA?

Everyone’s heard of THC (tetrahydrocannabinol) but most people don’t know about its precursor compound, THCA, which is found only in raw cannabis plants. As the buds dry, cure, or when heat is applied, THCA eventually turns into THC. This process – when THCA loses its carboxyl acid group – is known as decarboxylation. Contrary to popular belief, THC actually isn’t found in fresh flowers.

If you’ve ever bought cannabis from a dispensary that sends their bud out for lab-testing, you may have noticed that somewhere on the package it will have the “THC content” listed. It’s labeled this way because, presumably, the consumer is going to smoke, vape, or otherwise heat the product in some way. However, it would be more accurate to label it as “THCa content” since the flowers are raw when purchased.

For many years, this acid compound has been largely ignored and the central focus was on THC and finding ways to vilify it. Thankfully now, we’re starting to make great strides in the way of cannabis research and medical researchers are starting to look at the unique benefits of multiple cannabinoids, including THCA.

Unlike its decarbed counterpart, THCA is non-psychoactive, although very relaxing, and it does have numerous medical benefits. THCA can help with pain, inflammation, and neurological disorders like epilepsy. It has been found to contain neuroprotective qualities and can be a helpful compound in the treatment of Alzheimer’s, Parkinson’s, and Multiple Sclerosis. Also, in addition to the research I’m covering in this particular article, previous studies have suggested that THCA has some level of anti-cancer properties.

Cancer Statistics

In the United States alone, an estimated 1,806,590 new cases of cancer will be diagnosed in the coming year, and out of those cases, 606,520 will die from the disease or a related complication. The most common cancers, in descending order, are breast, lung, prostate, colon, melanoma, bladder, non-Hodgkin lymphoma, kidney/renal, endometrial, leukemia, pancreatic, thyroid, and liver cancer. In women, the most commonly diagnosed cancers are breast, lung, and colorectal, while for men the most common are prostate, lung, and colorectal. These 4 different types of cancer account for roughly 50% of all new cases.

Despite living in a nation that prides itself on having the best medical care on earth, cancer mortality rates remain high. For men, the number rate of death is higher with 190 per 100,000 – compared to 136 per 100,000 for women. There are race discrepancies as well, with cancer mortality being highest in African American men (227 per 100,000) and lowest in Asian/Pacific Islander women (86 per 100,000).

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Approximately 40 percent of American adults will be diagnosed with cancer at some point during their lives and an estimated 16,850 children and adolescents between the ages of 0 to 19 will receive a diagnosis. The cost of national cancer-related expenditures is around $160 billion. These numbers are all estimated to increase over the coming decades as a result of an aging population and exposure to environmental and dietary carcinogens.

Worldwide, cancer is among the leading causes of death. Every year around 18 million people are diagnosed with cancer, with roughly 9.5 million deaths. Generally, cancer rates are highest in countries whose populations have the highest life expectancy, education level, and standard of living, which tells us a few different things.

First, the obvious, incidence rates for cancer go up as age increases, so naturally, a population with a larger number of older citizens will have higher rates of cancer as well. Now, the less obvious, people in more developed nations live in a much more sedentary lifestyle and are exposed to a variety unnatural compounds over the course of their existence, many of which are carcinogenic. People living a simpler and more natural lifestyle are typically healthier overall.

Multiple Drug Resistance       

Although the number of available cancer treatments is growing, long term survival rates for patients undergoing traditional chemotherapy remain suboptimal. A major factor impacting the effectiveness of chemotherapy is the development of resistance to a variety of anticancer drugs. This is referred to as Multiple Drug Resistance (MDR) and it occurs in over 50 percent of cancer patients who experience a recurrence. Recurrence, coupled with MDR, greatly increases the risk of mortality.  

According to the study, “The dominant mechanism behind Multi Drug Resistance involves active extrusion of the cytotoxic drugs from the tumor cells by dedicated efflux pump proteins, that reduces the intracellular levels of cytotoxic drugs below lethal thresholds. Blocking the flow of chemotherapeutic drugs out of MDR cells by efflux pump inhibition has been for long a highly desirable approach for tumor resistance reversal, however the first two generations of chemosensitizers, drawn from drugs approved for other indications and their derivatives, did not progress to become established clinical modalities, mainly due to adverse effects and toxicity.”  

Simply put, MDR occurs via the increased release of drugs (chemotherapy drugs in this case) outside the cells, so drug absorption is reduced within the cells. There are many different mechanisms at play here, but the main point is that MDR is responsible for over 90 percent of deaths in cancer patients on chemotherapy drugs, and a solution to this problem is of utmost importance.

About the Study

According to this study, which was completed by SciCann Therapeutics in Israel, the THCA class of cannabinoids has potential as an MDR pump inhibitor, one that’s non-toxic, non-psychoactive, and free of dangerous side effects. Research on the subject is limited, but this particular study is very informative with incredibly promising results.

According to Professor Dan Peer from Faculty of Life Sciences at Tel Aviv University, “ the goal was to discover a set of potent cannabinoid compounds that would be safe and non-toxic for clinical use, however would show high efficacy in blocking cancer cell efflux pumps.” SciCann’s aims to develop a first in class cannabinoid “chemosensitizng agent to be administered as an add-on therpay together with traditional chemotherpay, for patients who have developed a Multi Drug Resistance cancer type and thus restore tumor response levels to therapy.”

This first test was conducted on the human ovarian adenocarcinoma resistant cell line (NAR) and its non-resistant parent line (OVCAR-8). MDR is one of the most common causes of chemotherapy failure in patients with ovarian cancer as well as secondary treatment failure that can lead to devastating outcomes.

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SciCann’s research program has already discovered numerous cannabinoids that can act as MDR efflux pump inhibitors. However, the most effective was THCA, which, according to their documents, “has demonstarted a very significant effect of efflux pump inhibition and synergistic activity with traditional chemotherapies”.

This study does not peg THCA as a cure for cancer, but rather as a treatment option that, when combined with other traditional cancer therapies, could greatly increase the likely hood of treatment success and a person’s chances for survival. In short, THCA can be used to re-sensitize tumors that have been previously unresponsive to other treatments.

SciCann has filed a very broad patent application that covers “any pharmaceutical composition that contains a combination of THCA and any anti-cancer or anti-bacterial drug substance, as well as the method of using THCA as a tumor cell or pathogen cell sensitizing agent. The international PCT patent office has found no relevant prior art in the literature for the THCA – chemo or antibiotics combination, or for the use of THCA as a chemo and antibiotics sensitizing agent, and therefore declared the invention as novel and patentable.”

Main Takeaway – THCA for Drug Resistant Cancer

THCA alone doesn’t kill cancer, at least, not according to this study. It does, however, help traditional chemotherapy and other cancer immunotherapy treatments work more efficiently by bypassing any existing Multi Drug Resistance, that is common in roughly half of all cancer patients. A combination of standard cancer therapies along with THCA could allow doctors to give much smaller doses of chemotherapy drugs to their patients, minimizing the risk of dangerous side effects and making survival much more likely.

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